Exonuclease 1 (Exo1) is required for activating response to SN1 DNA methylating agents
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چکیده
منابع مشابه
Homologous Recombination Rescues Mismatch-Repair-Dependent Cytotoxicity of SN1-Type Methylating Agents in S. cerevisiae
Resistance of mammalian cells to S(N)1-type methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) generally arises through increased expression of methylguanine methyltransferase (MGMT), which reverts the cytotoxic O(6)-methylguanine ((Me)G) to guanine, or through inactivation of the mismatch repair (MMR) system, which triggers cell death through aberrant processing of (Me)G/T ...
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Mitochondrial DNA (mtDNA) polymerase γ (POLγ) harbours a 3'-5' exonuclease proofreading activity. Here we demonstrate that this activity is required for the creation of ligatable ends during mtDNA replication. Exonuclease-deficient POLγ fails to pause on reaching a downstream 5'-end. Instead, the enzyme continues to polymerize into double-stranded DNA, creating an unligatable 5'-flap. Disease-a...
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[This corrects the article DOI: 10.1371/journal.pone.0160248.].
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1 Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece, 2 Institute of Molecular Biology and Genetics, Biomedical Sciences Research Centre ‘Alexander Fleming’, 16672 Vari, Greece, 3 Laboratory of Biotechnology, School of Chemical Engineering, National Technical University of Athens, 15780 Athens, Greece, 4 Enios Applications Pr...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2012
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2012.09.004